| SM Hírek : Cannabis extract did not have psychopathological or cognitive effects on MS patients in a clinical study |
Cannabis extract did not have psychopathological or cognitive effects on MS patients in a clinical study
2008.11.10. 02:16
According to a placebo-controlled clinical study conducted at the
University of Rome, Italy, the cannabis extract Sativex did not
cause psychopathological states or cognitive deficits in patients
with multiple sclerosis. In this 8-week crossover trial 17 patients
received Sativex and placebo for three weeks each.
Scores of investigated variables of psychopathology and cognition
after cannabis and placebo showed no significant differences. A
significant positive correlation was found between THC blood
levels and scores of aggressive behaviour and paranoiac
tendencies. Researchers concluded that "cannabinoid treatment
did not induce psychopathology and did not impair cognition in
cannabis-naïve patients with MS. However, the positive
correlation between blood levels of delta-9-tetrahydrocannabinol
and psychopathological scores suggests that at dosages higher
than those used in therapeutic settings, interpersonal sensitivity,
aggressiveness, and paranoiac features might arise."
(Source: Aragona M, Onesti E, Tomassini V, Conte A, Gupta S,
Gilio F, Pantano P, Pozzilli C, Inghilleri M. Psychopathological
and cognitive effects of therapeutic cannabinoids in multiple
sclerosis: a double-blind, placebo controlled, crossover study. Clin
Neuropharmacol. 2008 Oct 23. [Electronic publication ahead of
print])
IACM-Bulletin of 9 November 2008 (http://www.cannabis-med.org/)
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