SM Hírek : Mechanisms by which neurons are damaged in multiple sclerosis |
Mechanisms by which neurons are damaged in multiple sclerosis
2005.04.27. 23:52
Two studies reported on mechanisms by which neurons are damaged in multiple sclerosis (MS). Researchers in Germany and New York showed that when immune cells destroy the insulating myelin around neurons, a molecule called 7-ketocholesterol is released.
This molecule may stimulate other immune cells to attack the neuron. Understanding this important step may help design therapies to block it. [S12.004] Meanwhile, researchers from the United Kingdom discovered that in neurons from a mouse model, the number of mitochondria is increased, and the mitochondria are more active.
Mitochondria are the cell's power-generating plants, and it is possible that the increase reflects an increased need for energy in the vulnerable neurons. Neuronal loss may occur partly due to the inability to keep up with energy demands. [S12.005]
American Academy of Neurology 57th annual meeting Contact: Robin Thompson rthompson@aan.com 651-695-2763 American Academy of Neurology http://www.aan.com/press
New insights into risk factors for Parkinson's disease and stroke, new understanding of disease mechanisms in multiple sclerosis, and new treatment possibilities for pain, epilepsy, and ALS were among the scientific highlights at the 57th Annual Meeting of the American Academy of Neurology (AAN), where results from more than 1,400 scientific studies were presented. Some of the most important findings were presented in a plenary session moderated by John H. Noseworthy, MD, chair of the AAN Science Committee and Scientific Program Subcommittee and chair of the department of neurology at Mayo Clinic in Rochester, Minn.
The American Academy of Neurology, an association of more than 18,000 neurologists and neuroscience professionals, is dedicated to improving patient care through education and research. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer's disease, epilepsy, multiple sclerosis, Parkinson's disease, and stroke.
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